TABLE 3.

Inhibition of binding of Bocillin FL to PBPs by two beta-lactams

DrugE. faecalis strainIC50a (μg/ml)MIC (μg/ml)
PBP1PBP3PBP4PBP5
AmpicillinSEF9610.50.25>161
ATCC 2921210.50.25>161
SVR 25020.51>81
SVR 25120.50.25>81
SVR 3420.54>328
SVR 13820.54>328
SVR 111010.58>3216
SVR 111910.258>3216
ImipenemSEF960.50.250.25>161
ATCC 292120.50.250.125>161
SVR 25010.50.25>80.5
SVR 2510.50.250.5>80.5
SVR 340.50.254>324
SVR 1380.50.254>324
SVR 111010.532>3232
SVR 111910.2516>3232
  • a IC50, concentration of unlabeled antibiotic which reduces binding of Bocillin FL to a PBP by more than 50%.