TABLE 2

Detailed MICs of H. influenzae strain Rd and strains with acr mutations

StrainRelative acrB mRNA levelaMIC (μg/ml)Ratiob
CLRAZMCLRAZM
Rd0.82 ± 0.248111
Rd42acr1.86 ± 0.35c3083.88
Rd70acr1.45 ± 0.09c263.53.33.5
  • a The transcription levels were calculated in comparison with the gyrB transcription level. The measurements of acrB transcription levels were performed at least three times on independent occasions.

  • b Ratio of each MIC to that of H. influenzae Rd.

  • c P < 0.05, Rd versus Rd42acr and Rd versus Rd70acr.