TABLE 5

Experimental schemea

Treatment groupDrug regimenBoth strains or nude mice only?bNo. of mice sacrificed/total no. of miceTotal
0–2 mos2–6 mosMo 0.5Mo 1Mo 2Mo 4Mo 6
1Untreated +/+ 5/10 5/10
2P 5/7P 5/7+/+ 5/55/55/55/520/20
3RHZE 5/7RH 5/7+/+5/55/55/55/55/525/25
4P 1/70/+ 0/50/50/10
5PH50 1/7+/+ 5/55/510/10
62wRHZE 5/7 + 6wRH25Z300E200 2/7RH25 2/7+/+ 5/55/55/55/520/20
7P 1/70/+ 0/50/50/10
8PH50 1/7+/+ 5/55/510/10
9P15H50 1/70/+ 0/50/50/10
10P20H50 1/70/+ 0/50/50/10
112wRH5ZE 5/7 + 6wRH12.5Z300E200 2/7RH12.5 2/7+/+5/55/55/55/55/525/25
12P 1/70/+ 0/50/50/10
13PH25 1/7+/+ 5/55/510/10
14P15H25 1/70/+ 0/50/50/10
15P20H25 1/70/+ 0/50/50/10
Total 125/200c15/2020/2020/2035/7035/70125/200
  • a Drug doses (in mg/kg) if not otherwise specified: rifampin (R), 10; rifapentine (P), 10; isoniazid (H), 10; pyrazinamide (Z), 150; ethambutol (E), 100.

  • b +/+, arm included both BALB/c and nude mice; 0/+, arm included nude mice only.

  • c Four BALB/c mice sacrificed on day −17 and 6 nude mice sacrificed on day 0 were not included.