TABLE 1.

Serum doxycycline concentration, MIC, and outcome for 16 patients with Q fever endocarditisb

Patient no.No. of dilution decreaseSerum doxycycline level (μg/ml) after 1 yr of treatmentDoxycycline MIC (μg/ml)Serum/MIC ratioOutcomeDuration of treatment (mo)
103.8 ± 0.441.0Still under therapy22
202.5 ± 0.140.6Cured44
313.9 ± 0.541.0Deada19
412.2 ± 0.140.6Cured36
522.1 ± 0.240.5Cured60
622.7 ± 0.440.7Still under therapy24
734.0 ± 0.441.0Cured30
845.9 ± 0.623.0Cured35
943.9 ± 0.422.0Cured18
1044.0 ± 1.422.0Cured29
1143.2 ± 0.621.6Cured25
1254.7 ± 0.822.4Cured36
1358.3 ± 1.142.1Deada19
14102.9 ± 0.121.5Cured25
1554.5 ± 0.714.5Still under therapy30
1603.5 ± 0.680.4Dead14
  • a These patients died without suffering an evolutive Q fever.

  • b Patients 1 to 6 had decreases of IgG and/or IgA phase I antibody titers of ≤2 dilutions (group B). Patients 7 to 15 had decreases of IgG and/or IgA phase I antibody titers of ≥2 dilutions (group A). Patient 16 died during the course of treatment.