TABLE 1

In vitro interactions of caspofungin with fluconazole and voriconazole against Candida auris

Strain no.CAS + FLUbCAS + VRCb
MIC (μg/ml)FICI/INTMIC (μg/ml)FICI/INT
CASFLUCAS/FLUCASVRCCAS/VRC
VPCI 482/P/13a2≥641/320.75/IND221/0.50.75/IND
VPCI 1132/P/13a2321/80.75/IND20.51/0.0630.62/IND
VPCI 1133/P/13a4≥642/641/IND412/0.250.75/IND
VPCI 265/P/14a4322/321.5/IND482/0.250.75/IND
VPCI 1510/P/14a0.5320.5/322/IND0.540.5/42/IND
VPCI 1514/P/14a1≥640.5/320.75/IND10.51/0.251.5/IND
VPCI 266/P/14a2≥641/320.75/IND20.51/0.251/IND
VPCI 267/P/14a2321/80.75/IND20.52/0.0630.62/IND
VPCI 487/P/14a1≥640.5/80.56/IND110.5/0.1250.62/IND
VPCI 518/P/14a0.5≥640.25/80.56/IND0.510.25/0.250.75/IND
  • a Fluconazole-resistant isolates (n = 10).

  • b CAS, caspofungin; FLU, fluconazole; VRC, voriconazole; FICI, fractional inhibitory concentration index; IND, indifference; SYN, synergy; INT, interpretation.