TABLE 2

Mortality of nude mice during the treatment perioda

Treatment groupTreatment regimenNo. of mice showing mortality during the treatment period/total no. of mice
0–2 mos2–6 mos0–2 mos2–6 mosb
2P 5/7P 5/71/106/10 (6/6)
3RHZE 5/7RH 5/73/150/10
4P 1/71/10 (1/1)
5PH50 1/70/10
62wRHZE 5/7 + 6wRH25Z300E200 2/7RH25 2/72/100/10
7P 1/71/10 (1/1)
8PH50 1/70/10
9P15H50 1/70/10
10P20H50 1/70/10
112wRH5ZE 5/7 + 6wRH12.5Z300E200 2/7RH12.5 2/73/154/10 (3/4)
12P 1/73/10 (2/3)
13PH25 1/71/10 (?)
14P15H25 1/70/10
15P20H25 1/71/10 (0/1)
  • a Drug doses (in mg/kg) if not otherwise specified: rifampin (R), 10; rifapentine (P), 10; isoniazid (H), 10; pyrazinamide (Z), 150; ethambutol (E), 100. The mortality data include only mice dead from any cause before scheduled sacrifice or sacrificed earlier due to severe illness.

  • b Numbers within parentheses indicate the proportions of dying mice harboring ≥1% resistant CFU. ?, not assessable.