TABLE 3.

Properties of C. albicans laboratory strains with reduced caspofungin susceptibility

StrainFks1p mutationMICa (μg/ml) in:Glucan synthesis IC50 (ng/ml)Mouse ED90 (mg/kg)
RPMIAM3
CAI4S645/S6450.12<0.060.910.002
CAI4-R1S645/P645>32>20.5 and 1000.14
NR2S645/P645>32>2NDb0.09
NR4P645/S645>3210.5 and 1000.07
NR3Y645/Y645>32>225003.20
T25Δc/P645>32>21333.39
  • a Susceptibility testing was performed per CLSI protocol M27A2, except MIC values were defined as the lowest caspofungin concentration to reduce the OD600 to that of a media blank.

  • b Not determined.

  • c Δ indicates a disrupted Cafsk1 allele.