TABLE 4.

Echinocandin susceptibility of independent pGSC8 transformants of TIFOA

Transformant designationIntegration siteMICa
1Cafks1h::hisG2
2Cafks1h::hisG2
3Cafks1h::hisG2
8CaFKS1b2
4Unknownb<0003
5Unknown<0.003
pJAM11c in T1FOAURA3d<0.003
pJAM11 in CAI4-R1URA34
  • a The MIC for L-733560 was defined as the lowest drug concentration that reduced the OD600 to that of media. Values are the average of 3 independent experiments in YPD broth.

  • b Not integrated at CaFKS1b or Cafks1h::hisG.

  • c Ura* control plasmid.

  • d Site of integration unproven.