TABLE 2.

MICs for E. coli XL-1 Blue cells harboring SME-1, SME variants, TEM-1, and pTP123 vector

MutantMIC (μg/ml) for drug:
AmpicillinImipenemCefotaxime
SME-11,750500.0625
SME Y104A2,000700.125
SME Y104G1,750640.0625
SME Y104P62.5320.03125
SME Y104V62.5320.03125
SME Y104W500700.125
SME H105R12541.0
SME H105W2,000800.0625
SME H105Y2,000800.0625
SME N132I62.50.50.0625
SME N132S62.50.50.03125
SME S237G31.250.50.03125
SME S237Q62.50.50.03125
SME S237T2,000320.250
SME Y241F1,750320.0625
SME Y241W1,50040.0625
TEM-12,00010.03125
pTP12320.06250.03125