TABLE 1.

Laboratory and clinical mutant strains used in this study

StrainGenotype or origin, source, and day of therapyReference or source
S. cerevisiae strains
    YFK978MATa ade2-101 his3-Δ200 leu2- Δ1 lys2-801 trp1-Δ1 ura3-52 fks1-1 cnb1::LYS2 fks2-1 (pDL1)This work
    R560-1CMATa ade2-1 can1 his3-11,15 leu2-3,112 trp1-1 ura3-1 fks1-212
    MS10MATa fks1-315
    MS14MATa fks1-415
    YFK931-7BMATa ade2-101 his3-Δ200 leu2-Δ1 lys2-801 trp1-Δ1 ura3-52 fks1-1 cnb1::LYS2(pDL1)This work
    YLIP179MATα ade2-1 can1 his3-11,15 leu2-3,112 trp1-1 ura3-1 fks1::HIS311
C. albicans laboratory strains
    CA14Δura3::imm434/Δura3::imm43416
    CA14-R1Δura3::imm434/Δura3::imm434 Cafks1h-1/CaFKS122
    NR2Δura3::imm434/Δura3::imm434 Cafks1h-2/CaFKS1b22
    NR3Δura3::imm434/Δura3::imm434 Cafks1h-3/Cafks1h-322
    NR4Δura3::imm434/Δura3::imm434 CaFKS1/Cafks1b-422
    T25Δura3::imm434/Δura3::imm434 Cafks1h-1/Cafks1b::URA310
    T28Δura3::imm434/Δura3::imm434 Cafks1h-1::URA3/CaFKS110
    T1FOAΔura3::imm434/Δura3::imm434 Cafks1h::hisG/CaFKS1b10
Candida clinical strains
    CLY16996 (C. albicans)Patient A, blood, day 14This work
    CLY16997 (C. albicans)Patient A, lung, postmortemThis work
    CLY19230 (C. albicans)Patient B, oral mucosa, day 27This work
    CLY19231 (C. albicans)Patient B, oral mucosa, day 28This work
    CLY16038 (C. krusei)Patient C, stool, day 17This work