TABLE 2.

Scores for inflammatory response, infiltrating neutrophils and mononuclear leukocytes, and presence of bacteria

Group, day, and parameterMeanaSDUntreatedPlacebo
MeanSDMeanSD
Tape-stripped skin
    Day 0 (n = 8)
        Inflammation score
            Dermal0.00.0
            Subcutaneous0.10.4
            Muscular0.00.0
            Connective tissue0.00.0
        Neutrophils0.00.0
        Mononuclear leukocytesb0.00.0
        Presence of bacteria0.00.0
    Day 4 (n = 8)
        Inflammation score
            Dermal0.81.4
            Subcutaneous2.60.5
            Muscular0.30.7
            Connective tissue1.31.3
        Neutrophils0.30.3
        Mononuclear leukocytesb0.00.0
        Presence of bacteria0.00.0
S. aureus, day 4c
    Inflammation score
        Dermal1.31.20.00.0
        Subcutaneous2.50.82.40.9
        Muscular0.40.51.61.1
        Connective tissue0.40.51.10.5
    Neutrophils0.60.60.50.4
    Mononuclear leukocytesb0.40.21.21.7
    Presence of bacteria0.60.73.00.0
S. pyogenes, day 4d
    Inflammation score
        Dermal0.00.01.21.3
        Subcutaneous2.80.52.21.3
        Muscular0.30.51.61.1
        Connective tissue0.51.01.10.5
    Neutrophils0.30.50.70.3
    Mononuclear leukocytesb0.30.31.70.7
    Presence of bacteria0.30.32.41.3
  • a Scoring quantification is described in Materials and Methods.

  • b Mononuclear leukocytes include lymphocytes and histiocytes.

  • c Eight mice were in the untreated group and six mice were in the placebo group.

  • d Five mice were in the untreated group and five mice were in the placebo group.