TABLE 2.

Macroscopic lung scores at different time points after intratracheal challenge and novispirin G10 administration

Treatment or parameter% of ratsa
Day 3 (n1 = n2 = 14)Day 5 (n1 = n2 = 14)Day 7 (n1 = n2 = 11)Day 10 (n1 = 14, n2 = 12)
I + IIcIIIIVI + IIIIIIVI + IIIIIIVI + IIIIIIV
Novispirin G10021.478.628.671.4054.545.5078.621.40
Placebo control0010000100036.463.68.333.358.3
P value (χ2 test)NSbNSNSNS<0.001<0.001<0.005NS<0.005<0.001NS<0.001
  • a n1 and n2 are the animal numbers in the novispirin G10-treated and control groups.

  • b NS, not significant.

  • c See Materials and Methods.