TABLE 3.

Pulmonary cytokine responses at different time points post lung bacterial challenge with and without treatment

CytokineMean cytokine response ± SDa
Day 3Day 5Day 7
NovispirinControlNovispirinControlNovispirinControl
IFN-γ65.29 ± 28.58c115.88 ± 42.99116.61 ± 42.08114.12 ± 11.8679.91 ± 16.2286.96 ± 26.20
TNF-α159.21 ± 23.81d219.22 ± 48.82128.11 ± 19.04d178.52 ± 38.05121.76 ± 19.63140.90 ± 36.78
IL-434.49 ± 4.49b42.45 ± 8.4245.32 ± 5.9147.96 ± 4.5437.34 ± 5.9252.87 ± 38.99
IL-674.08 ± 10.01b91.05 ± 23.3665.23 ± 11.1166.97 ± 11.7161.54 ± 11.0156.91 ± 12.95
IL-1051.67 ± 2.63e70.45 ± 6.8457.76 ± 7.5862.87 ± 8.4751.31 ± 2.8853.68 ± 8.97
  • a n1 = n2 = 10.

  • b Compared with the control group (ANOVA), P < 0.05.

  • c Compared with the control group (ANOVA), P < 0.01.

  • d Compared with the control group (ANOVA), P < 0.005.

  • e Compared with the control group (ANOVA), P < 0.001.