TABLE 2.

Pharmacokinetic parameters following the administration of pyrimethamine-sulfadoxine in patients with acute uncomplicated P. falciparum malariaa

ParameterACPR (n = 49)LTF (n = 66)P value
Day 3 blood SDX (μg/ml)77.1 ± 48.1 (0.23-230)61.3 ± 42.3 (0.0935-213)0.061
Day 3 blood PYR (ng/ml)267 ± 165 (245-668)216 ± 130 (17.6-513)0.083
SDX elimination half-life (days)7.156.410.42
AUC0-∞ (μg day ml−1) ± SE932 ± 100888 ± 78.90.72
C0 (SDX, μg/ml) ± SE79 ± 6.5269 ± 6.270.60
  • a Values are means±SEM, with ranges in parentheses. See text for dosages. AUC0-∞ is for sulfadoxine.