TABLE 3.

Univariate comparison of the characteristics of children who cleared and those who failed to clear the PYR-SDX-resistant P. falciparum quintuple-mutant infectiona

ParameterCleared quintuple mutant (n = 31)Failed to clear quintuple mutant (n = 43)P valueb
Gender ratio (male:female)14:1727:160.16
Age (yr)2.54 ± 0.632.11 ± 0.240.49
Weight (kg)10.6 ± 0.9610.1 ± 0.500.25
Parasitemia (parasites/μl)8,920 ± 1,3398,217 ± 1,5340.32
Baseline hemoglobin (g/liter)8.0 ± 0.467.7 ± 0.270.60
Baseline blood folate (ng/ml)29.5 ± 1.8734.2 ± 1.570.056
Day 3 SDX (μg/ml)69.8 ± 8.4365.3 ± 7.010.72
Day 3 PYR (ng/ml)305 ± 35.4228 ± 21.70.037*
  • a Parasite densities are reported as geometric means. The rest of the values are means ± SEM.

  • b The P value with an asterisk is significant at <0.05.