TABLE 1.

gyrA and gyrB QRDR mutations of in vitro isolates of M. tuberculosis H37Rv grown on plates containing MXF (1, 2, and 4 μg/ml)

MXF concn (μg/ml)IsolateQRDR mutation, codon sequence change
gyrAgyrB
1.0AD94G, GAC→GGCNone
BD94Y, GAC→TACNone
CD94G, GAC→GGCNone
DD94Y, GAC→TACNone
ED94G, GAC→GGCNone
2.0AD94G, GAC→GGCNone
BD94N, GAC→AACA543E, GCG→GAG
CD94G, GAC→GGCNone
DD94Y, GAC→TACNone
ED94Y, GAC→TACNone
4.0AG88C, GGC→TGCNone
BD94G, GAC→GGCNone
CG88C, GGC→TGC1538S, ATC→AGC
DD94Y, GAC→TACNone
EG88C, GGC→TGCNone