TABLE 1.

Survival times for mice infected with A. fumigatus AZN 8196 and treated with different 5FC dosing regimensa

Treatment groupTotal daily dose (mg/kg/day)Survival (%)Median (range) survival time (days)
200 mg/kg/q6h8009014 (4-14)b
100 mg/kg/q6h4009014 (5-14)b
50 mg/kg/q6h2007014 (5-14)b
25 mg/kg/q6h1005014 (3-14)c
12.5 mg/kg/q6h50406 (3-14)
200 mg/kg/q12h4008014 (3-14)b
100 mg/kg/q12h200408 (3-14)
50 mg/kg/q12h1006014 (6-14)b
25 mg/kg/q12h50409.5 (3-14)
200 mg/kg/q24h2005014 (4-14)d
100 mg/kg/q24h1006014 (3-14)d
Control group204 (2-14)
  • a Treatment was started 2 h after infection and continued for 7 days.

  • b P < 0.01 (compared with controls).

  • c P < 0.1 (compared with controls).

  • d P < 0.05 (compared with controls).