TABLE 2.

MIC changes in S. aureus upon overexpression of the MetS target

Antimicrobial agentS. aureus RN4220 MIC (μg/ml)
pYH4 vector controlapYH4-metSa
− aTc inducer+ aTc inducer− aTc inducer+ aTc inducer
REP88390.0080.0080.121
Mupirocin0.060.060.060.06
Novobiocin0.250.250.250.25
Vancomycin110.50.5
  • a In the presence (+) or absence (−) of anhydrotetracycline (aTc) inducer.