TABLE 1.

Antibacterial-effect (Δ24)-moxifloxacin exposure relationships for E. coli (aerobic and anaerobic conditions), B. fragilis, C. perfringens, and GPAC

EffectIsolate
E. coliB. fragilisC. perfringensGPAC
AerobicAnaerobic
Minimum effect (log CFU/ml)+1.4 ± 0.5+1.5 ± 0.2+1.4 ± 0.5+2.2 ± 0.4+1.3 ± 0.3
Maximum effect (log CFU/ml)−4.4 ± 0.3−4.5 ± 0.2−3.2 ± 0.2−3.7 ± 0.12.5 ± 0.1
AUC/MIC for static effect26417.67.65.6
−1-log kill30.94910.79.18.7
−2-log kill37.25916.211.215.5
−3-log kill44.76937.215.2>216
−4-log kill66.198>216>216>216
50% effect34 (26-44)54 (37-79)10.5 (8-13.8)8.6 (7.5-9.8)7.3 (5.6-9.4)
90% effect599625.716.217.4
99% effect10514881.031.642.7
r2 for fit0.860.980.900.930.94