Antibacterial-effect (Δ24)-moxifloxacin exposure relationships for E. coli (aerobic and anaerobic conditions), B. fragilis, C. perfringens, and GPAC
| Effect | Isolate | ||||
|---|---|---|---|---|---|
| E. coli | B. fragilis | C. perfringens | GPAC | ||
| Aerobic | Anaerobic | ||||
| Minimum effect (log CFU/ml) | +1.4 ± 0.5 | +1.5 ± 0.2 | +1.4 ± 0.5 | +2.2 ± 0.4 | +1.3 ± 0.3 |
| Maximum effect (log CFU/ml) | −4.4 ± 0.3 | −4.5 ± 0.2 | −3.2 ± 0.2 | −3.7 ± 0.1 | 2.5 ± 0.1 |
| AUC/MIC for static effect | 26 | 41 | 7.6 | 7.6 | 5.6 |
| −1-log kill | 30.9 | 49 | 10.7 | 9.1 | 8.7 |
| −2-log kill | 37.2 | 59 | 16.2 | 11.2 | 15.5 |
| −3-log kill | 44.7 | 69 | 37.2 | 15.2 | >216 |
| −4-log kill | 66.1 | 98 | >216 | >216 | >216 |
| 50% effect | 34 (26-44) | 54 (37-79) | 10.5 (8-13.8) | 8.6 (7.5-9.8) | 7.3 (5.6-9.4) |
| 90% effect | 59 | 96 | 25.7 | 16.2 | 17.4 |
| 99% effect | 105 | 148 | 81.0 | 31.6 | 42.7 |
| r2 for fit | 0.86 | 0.98 | 0.90 | 0.93 | 0.94 |