TABLE 1

Antimicrobial activity of ceftazidime-avibactam tested against antimicrobial resistant Enterobacteriaceae and P. aeruginosa from U.S. hospitals (2013 to 2016)a

Organism (no. of isolates)No. of isolates and cumulative % at various MICs (μg/ml)bMIC (μg/ml)
≤0.0150.030.060.120.250.512481632>32MIC50MIC90
Enterobacteriaceae (36,380)1,3344,42811,13912,3424,8151,631448142631513190.120.25
3.715.846.580.493.698.199.399.799.999.9>99.9>99.9100.0
    CRE (513)165133576137138592014090.52
3.14.16.613.528.355.081.993.497.397.598.298.2100.0
    MDR (2,953)98217428597587525296116531313190.251
3.310.725.245.465.383.093.197.098.899.299.799.7100.0
    XDR (448)169202553126117442354060.52
3.65.610.015.627.555.681.791.596.797.898.798.7100.0
E. coli (12,942)1,0241,4634,5974,5501,0661863613310030.060.25
7.919.254.789.998.199.699.899.9>99.9>99.9>99.9>99.9100.0
    Ceftriaxone-NS (1,750)100632477364441083312310030.120.25
5.79.323.465.590.997.098.999.699.899.899.899.8100.0
    MEM-NS (27)11358411000030.25>32
3.77.418.537.066.781.585.288.988.988.988.988.9100.0
K. pneumoniae (7,511)1373642,5232,950957364137581701030.120.25
1.86.740.379.592.397.198.999.799.999.9>99.9>99.9100.0
    MEM-NS (382)1557215611199481601030.52
3.95.27.112.627.256.382.294.899.099.099.299.2100.0
    Ceftriaxone-NS (1,063)392367259242229127561701030.251
3.75.812.136.559.380.892.898.099.699.699.799.7100.0
    Colistin-NS (205)94224930363213900010.252
4.46.317.141.055.673.288.895.199.599.599.599.5100.0
K. oxytoca (1,902)8938237091747414511 0.120.25
0.45.348.685.995.098.999.699.999.9100.0
Proteus mirabilis (2,818)421,5681,1028314330110010.030.06
1.557.196.299.299.799.899.999.999.9>99.9>99.9>99.9100.0
E. cloacae (3,740)33262151,5941,18447716433803120.250.5
0.91.67.349.981.694.498.799.699.899.899.999.9100.0
    CAZ-NS (831)13374422934514630803120.51
1.61.92.88.135.677.194.798.399.399.399.699.8100.0
E. aerogenes (1,384)294735260525675104501 0.120.25
2.15.530.974.693.198.699.399.699.999.9100.0
    CAZ-NS (279)10717641134994501 0.250.5
3.66.112.235.175.693.296.497.899.699.6100.0
Morganella morganii (1,059)2370489120402592101 0.060.12
0.235.181.392.696.498.899.699.899.999.9100.0
Citrobacter koseri (777)3494373205601001 0.060.12
4.416.564.590.998.699.999.9100.0
Citrobacter freundii (1,026)12151714732259823261 0.120.5
1.22.619.365.487.396.999.199.399.9100.0
Serratia marcescens (1,715) 449720668233315122 0.250.5
0.23.145.184.097.699.499.799.899.9100.0
Proteus vulgaris (418)31861853824 0.060.12
0.745.289.598.699.0100.0
Providencia spp. (872)51641842311497414191895 0.120.5
0.619.440.567.084.192.594.296.398.499.4100.0
P. aeruginosa (7,868) 1413882,7712,7791,137426134434924
1.86.741.977.391.797.198.899.4100.0
    CAZ-NS (1,204) 117933173442161334349416
0.10.20.78.534.863.481.392.495.9100.0
    MEM-NS (1,471) 481213824852821073745416
0.30.89.035.068.087.294.496.9100.0
    P-T-NS (1,497) 21151083604673361253944416
0.10.21.28.432.563.786.194.597.1100.0
    CAZ, MEM, and P-T-NS (628) 221061741491013541832
3.520.448.171.887.993.5100.0
    MDR (1,562) 8181293844983141224247416
0.51.79.934.566.486.594.397.0100.0
    XDR (717) 10132126190194933644832
0.10.10.34.722.348.875.988.893.9100.0
  • a Abbreviations: CRE, carbapenem-resistant Enterobacteriaceae; MDR, multidrug resistant; XDR, extensively drug resistant; NS, nonsusceptible; MEM, meropenem; CAZ, ceftazidime; P-T, piperacillin-tazobactam.

  • b For each entry in column 1, there are two rows of data. The first row indicates the number of strains, and the second row indicates the cumulative percentage. Column subheadings specify the various MICs in μg/ml.