TABLE 1.

Number of viable M. tuberculosis organisms recovered from whole organs of drug-treated guinea pigs following 6 weeks of treatmenta

TreatmentRegimenLog10 CFU ± SEM
LungMLNSpleen
Pretreatment controlsNone6.15 ± 0.316.10 ± 0.015.94 ± 0.03
Sucrose controlsDaily5.48 ± 0.215.22 ± 0.055.33 ± 0.15
Empty PLG-NPEvery 10 days5.01 ± 0.424.98 ± 0.175.22 ± 0.40
Nonencapsulated drugsDaily3.75 ± 0.182.11 ± 0.482.27 ± 0.65
Drug-loaded PLG-NPEvery 10 days4.14 ± 0.233.28 ± 0.232.15 ± 0.37
  • a Viable bacterial counts were converted to logarithms and analyzed by one-way analysis of variance followed by an all-pairwise multiple comparison procedure utilizing the Fisher least significant difference method for the analysis of lung data and the Student-Newman-Keuls method for MLN and spleen data (SigmaStat v.2.03, SPSS Inc.).