TABLE 2.

Antibacterial effects of moxifloxacin on B. fragilis, C. perfringens, and GPAC at AUC/MIC ratios of 9 to 216 and Cmax/MIC ratios of 0.8 to 19.2

AUC/MICCmax/MICB. fragilisC. perfringensGPAC
T99.9 (h)AUBKC0-24AUBKC0-48T99.9 (h)AUBKC0-24AUBKC0-48T99.9 (h)AUBKC0-24AUBKC0-48
90.8>4890.1 ± 2.8158.0 ± 0.2>4877.4117.4>4878.7 ± 2.7124.9 ± 8.0
181.62962.7 ± 3.178.5 ± 7.7>4833.2 ± 1.944.8 ± 5.54860.4 ± 0.794.0 ± 0.5
363.2>4862.2 ± 2.090.2 ± 8.8525.7 ± 0.926.0 ± 0.74860.2 ± 4.278.9 ± 4.6
726.4723.3 ± 6.638.8 ± 1.8728.1 ± 2.238.3 ± 6.13655.2 ± 3.977.2 ± 10.4
21619.22448.2 ± 0.559.8 ± 4.11225.1 ± 1.132.3 ± 2.02758.1 ± 3.473.1 ± 17.0