TABLE 1

Activity of small molecules against M. bovis BCG and INH-susceptible and INH-resistant M. tuberculosis H37Rv and cytotoxicity against THP-1 macrophages

Serial no.NSC no.MIC99 (μM)CC50 (μM) against THP-1 macrophages
M. bovis BCGM. tuberculosis H37RvM. tuberculosis H37Rv INHr
1NSC 184153.1256.253.125>25
2NSC 1221311.252.5NDaND
3NSC 42631.561.563.125>25
4NSC 263711.562525>25
5NSC 949450.781.561.56>25
6NSC 1492861.561.563.125>25
7NSC 691871.563.1253.1255
8NSC 1255311.563.1251.56>25
9NSC 1390211.563.1253.125>25
10NSC 2281550.781.561.56>25
11NSC 471476.253.1256.255
12NSC 833180.3912.512.5>25
13NSC 1058270.781.563.1255
14NSC 603391.563.1253.125>25
15NSC 603400.393.1253.125>25
16NSC 674366.252525>25
17NSC 38526.2512.512.55
18NSC 2851663.12512.512.5>25
19NSC 1489586.255025>25
20NSC 42806.256.253.125>25
21NSC 1635010.780.39ND>25
22NSC 6595013.1253.1253.125>25
23NSC 6977260.391.563.1255
24NSC 3285873.1251.563.1255
25NSC 821166.2512.512.5>25
26NSC 69363212.512.525>25
27NSC 6878490.781.561.56>25
28NSC 2738291.566.256.25>25
29NSC 1833591.560.78ND5
30NSC 3111531.561.56ND>25
31NSC 6412451.566.25ND>25
32NSC 1453661.561.56ND5
33NSC 6906340.391.561.565
34NSC 2184390.390.390.39>25
35NSC 100101.56–3.1256.253.1255
36INH0.39–0.780.39–0.78>50>25
  • a ND, not done.