TABLE 3

MICs for various resistant strains in vitro

StrainMIC (μM)
PA-824NSC 4263LevofloxacinINH
NSC 4263-resistant mutant strains
    M. bovis BCG (wild type)0.781.560.780.78
    4263 (resistant mutant 1, FbiB)>5012.50.780.78
    4263 (resistant mutant 2, FbiB)>5012.50.780.78
    4263 (resistant mutant 3, FbiB)>5012.50.780.78
    4263 (resistant mutant 4, FbiB)>5012.50.780.78
    4263 (resistant mutant 5, FbiB)>5012.50.780.78
    4263R::pVV16-FbiB 11.561.560.780.78
    4263R::pVV16-FbiB 21.561.560.780.78
PA-824-resistant mutant strains
    H37Rv (wild type)0.781.560.780.78
    T3-MT (FGD F420+)>50250.780.78
    50-5A1 (FGD FbiC)>50250.780.78
    50-14A1 (FGD+ Ddn)>501.560.780.78
    50-7A2 (FGD+ FbiAB)>50250.780.78
    50-14A1-3547 (50-14A1::Rv3547)0.781.560.780.78