TABLE 1.

Comparison of EC50 values of mycophenolic acid, ribavirin, and glycyrrhizin obtained from three HTS assays in BHK-21 and Vero cellsa

Assay systemEC50 (μM)
Mycophenolic acidRibavirinGlycyrrhizin
Rluc-Neo-Rep BHK-21 cells1.4 ± 0.4818 ± 0.68>300
Rluc-Neo-Rep Vero cells0.08 ± 0.015119 ± 63>300
VLP BHK-21 cell infection0.04 ± 0.0021.1 ± 0.09>300
VLP Vero cell infection0.02 ± 0.00434 ± 0.92>300
Rluc-WNV BHK-21 cell infection0.08 ± 0.011.2 ± 0.005>300
Rluc-WNV Vero cell infection0.04 ± 0.0230 ± 2.51>300
  • a The data represent the means ± standard deviations (n ≥ 3).