TABLE 2.

Mean parameter values for each of the doses studied after the Bayesian step

Parametera0.25 mg/kg (n = 37)0.5 mg/kg (n = 36)1.0 mg/kg (n = 20)1.5 mg/kg (n = 37)
Vc (liter)0.001800.002480.002150.00209
SCL (liter/h)0.0005190.0005170.0005240.000509
k12 (h−1)12.2615.4211.6812.27
k21 (h−1)17.2817.5718.2018.05
k13 (h−1)8.1058.9778.7868.702
k31 (h−1)1.1730.8881.3031.198
Vkid (liter)0.004970.007140.005220.00539
ka (h−1)34.9730.6833.6133.48
  • a The pharmacokinetic parameters are defined in footnote a of Table 1.