TABLE 4.

Values of AUC0-96/MIC ratio, peak/MIC ratio, and T > MIC obtained for the caspofungin doses and their different schedules of administration

Total daily dose (mg/kg)One dose (0 h)Two doses (0 and 48 h)Four doses (0, 24, 48, and 72 h)Difference in AUCs (%) generated by giving one vs four divided doses
AUC0-96/MIC ratioa
    0.123.5221.5419.7416.1
    0.247.0443.0739.4716.1
    0.479.867.5860.0524.7
    1.0227.85205.20186.4518.2
Peak/MIC ratiob
    0.10.770.39, 0.460.19, 0.28, 0.32, 0.34
    0.21.50.77, 0.930.39, 0.56, 0.64, 0.68
    0.41.70.84, 1.20.42, 0.69, 0.87, 0.99
    1.06.73.40, 4.21.70, 2.50, 2.90, 3.10
Time > MIC (% of 96 h)
    0.1000
    0.213.500
    0.430.210.40
    1.069.894.893.8
  • a The AUC values are those that actually developed from 0 to 96 h. The MIC for caspofungin for the C. albicans isolate was 0.2 mg/liter.

  • b Multiple ratios are achieved for fractionated schedules.