TABLE 3.

Analysis of variance for the effect of dose fractionation (mg/kg) on Candida colony counts determined from the kidney after 96 h of caspofungin therapy

Total dose over 96 h (mg/kg)Colony count (log CFU/g ± 1 SD)P valuea
One dose (given at 0 h)Two half doses (given at 0 and 48 h)Four quarter doses (given at 0, 24, 48, and 72 h)
04.97 ± 0.34
0.14.58 ± 0.224.71 ± 0.274.70 ± 0.210.6
0.24.05 ± 0.434.37 ± 0.214.68 ± 0.580.19
0.43.54 ± 0.263.50 ± 0.443.95 ± 0.190.18
1.02.83 ± 0.472.77 ± 0.342.87 ± 0.390.92
5.02.47 ± 0.57
  • a A P value of <0.05 was statistically significant.