TABLE 1.

Parameter values and their dispersions for the Non-Parametric Adaptive Grid population pharmacokinetic analysis for caspofungin administered to mice as a single i.p. dose

ParameteraMeanMedianStandard deviation
Vc (liter)0.008460.001710.0180
SCL (liter/h)0.0006520.0005610.000428
k12 (h−1)1.7641.4071.178
k21 (h−1)28.4729.031.603
k13 (h−1)18.0518.822.230
k31 (h−1)3.2841.0035.334
Vkid (liter)0.004890.03860.00312
ka (h−1)32.1231.880.897
  • a Vc, volume of the central compartment; SCL, serum clearance; k12, k21, k13, and k31, first-order intercompartmental transfer rate constants, where k12 and k21 are the transfer rate constants between the central compartment and the extracellular and tissue sites of the mouse (excluding the kidneys) and k13 and k31 are the transfer rate constants between the central compartment and the kidneys; Vkid, volume of the kidney compartment; ka, first-order absorption rate constant for the i.p. injection.