Parameter^{a} | Mean | Median | Standard deviation |
---|---|---|---|

V (liter)_{c} | 0.00846 | 0.00171 | 0.0180 |

SCL (liter/h) | 0.000652 | 0.000561 | 0.000428 |

k_{12} (h^{−1}) | 1.764 | 1.407 | 1.178 |

k_{21} (h^{−1}) | 28.47 | 29.03 | 1.603 |

k_{13} (h^{−1}) | 18.05 | 18.82 | 2.230 |

k_{31} (h^{−1}) | 3.284 | 1.003 | 5.334 |

V_{kid} (liter) | 0.00489 | 0.0386 | 0.00312 |

k (h_{a}^{−1}) | 32.12 | 31.88 | 0.897 |

↵

*a**V*, volume of the central compartment; SCL, serum clearance;_{c}*k*_{12},*k*_{21},*k*_{13}, and*k*_{31}, first-order intercompartmental transfer rate constants, where*k*_{12}and*k*_{21}are the transfer rate constants between the central compartment and the extracellular and tissue sites of the mouse (excluding the kidneys) and*k*_{13}and*k*_{31}are the transfer rate constants between the central compartment and the kidneys;*V*_{kid}, volume of the kidney compartment;*k*, first-order absorption rate constant for the i.p. injection._{a}