TABLE 3.

Compartmental PK parameters

ParameterSubjectsaP
CFHealthy volunteers
Vc (liters)64.8 (22.8)44.4 (27.4)0.31
K10 (h−1)0.492 (0.650)0.692 (0.691)<0.01
Ka (h−1)0.483 (0.877)0.452 (0.274)0.60
Lag time (h)0.500 (0.498)0.500 (1.03)0.29
F (%)34.8 (13.5)40.1 (17.8)0.34
Vp (liters)412 (232)557 (367)0.28
Kcp (h−1)0.759 (0.394)1.22 (0.617)0.03
Kpc (h−1)0.120 (0.171)0.157 (0.0759)0.93
Vcell (liters)5.40 (3.05)4.59 (5.21)0.88
Kcl (h−1)0.282 (0.459)0.671 (0.437)0.41
Klc (h−1)0.0151 (0.00777)0.0109 (0.00604)0.98
  • a Median values are shown, with the standard deviation given in parentheses.