TABLE 2.

Noncompartmental PK parameters

ParameterSubjectsaP
CFHealthy volunteers
Cmax (μg/liter)567 (307)304 (344)0.29
Tmax (h)3.00 (1.5)3.00 (1.81)0.78
AUC0-96 (h · μg/liter)4,407 (1,507)4,365 (1,936)0.85
F (%)34.2 (13.6)42.8 (13.4)0.37
  • a Median values are shown, with the standard deviation given in parentheses.