TABLE 3.

Relative ERG11 and UPC2 transcript levels in FLUS and FLUR clinical isolate pairsc

StrainaMICFLU (μg/ml)bERG11UPC2
1002 (S)0.2511
3795 (R)>646.4 (±1.2)2.0 (±0.6)
580 (S)111
2440 (R)324.0 (±0.1)5.5 (±0.2)
945 (S)411
1619 (R)323.7 (±0.3)9.6 (±0.3)
5044 (S)411
5052 (R)321.9 (±0.3)2.7 (±0.1)
  • a Matched fluconazole-susceptible (S) and -resistant (R) isolates are grouped together.

  • b MIC data are from reference 14 (24-h readings).

  • c ERG11 and UPC2 mRNA levels of the susceptible isolates were set as 1.