TABLE 3.

Distribution and corresponding carbapenem MIC ranges for strains with different resistance determinants

Resistance determinant profileNo. of isolatesMIC (μg/ml) range
ImipenemMeropenemErtapenem
IMP-4+, no porin loss or decreased expression42-442-4
IMP-4+, single porin loss38832
IMP-4+, double porin loss116832
KPC-2+, single porin loss or decreased expression58-164-168-32
KPC-2+, double porin loss1>256256>256
IMP-8+, double porin loss2824-8
Carbapenemase, ESBL+, AmpC, single porin loss or decreased expression21-21-24-8
Carbapenemase, ESBL+, AmpC, double porin loss112-324-1616-128
Carbapenemase, ESBL, AmpC+, single porin loss1848
Carbapenemase, ESBL, AmpC+, double porin loss or decreased expression54-322-1616-64
Carbapenemase, ESBL+, AmpC+, double porin loss or decreased expression124-322-1632-128
Carbapenemase, ESBL, AmpC, single porin loss140.1250.064
Carbapenemase, ESBL, AmpC, double porin loss or decreased expression14432