TABLE 3.

KPC-2 inhibitor kinetics with the β-lactamase inhibitorsa

DrugKm (μM)kinact (s−1)kinact/Km ratio (μM−1 s−1)tn (kcat/kinact)
Clavulanate8.4 ± 0.80.027 ± 0.0010.0036 ± 0.0004∼2,500
Sulbactam135 ± 10.16 ± 0.010.0012 ± 0.0001∼1,000
Tazobactam78.5 ± 7.90.20 ± 0.010.0025 ± 0.0002∼500
Penem 10.06 ± 0.010.011 ± 0.0010.18 ± 0.02∼250
Penem 20.006 ± 0.0010.039 ± 0.0026.5 ± 0.6∼25
  • a Values are means ± standard deviations.