TABLE 3.

Individual and cumulative sensitivities of drug-resistant mutation sites in Mycobacterium tuberculosis compared with phenotypic resistance to isoniazid and rifampin in 242 phenotypically MDR isolates from Shanghai, China

Mutation siteIndividual sensitivity95% CI% Sensitivity (cumulative)95% CI% Specificity (individual)
No. of isolates detected/total no. of isolates% Sensitivity
Mutations associated with phenotypic isoniazid resistance
    katG315176/24272.766.7-78.272.766.7-78.2100
    inhA-1520/2428.35.1-12.478.572.8-83.5100
    ahpC-109/2423.71.7-6.980.675.0-85.4100
    ahpC-67/2422.91.2-5.983.177.7-87.6100
    ahpC-126/2422.50.9-5.385.580.5-89.7100
    ahpC-394/2421.70.5-4.286.481.4-90.4100
    inhA-84/2421.70.5-4.386.481.4-90.4100
    ahpC-93/2421.20.2-3.687.682.8-91.5100
    inhA252/2420.80.1-3.087.682.8-91.5100
    ahpC-322/2420.80.1-3.088.083.2-91.8100
    ahpC-152/2420.80.1-3.088.483.7-92.2100
    katG2951/2420.40.0-2.388.884.2-92.5100
    katG2991/2420.40.0-2.388.884.2-92.5100
    katG3221/2420.40.0-2.389.384.7-92.9100
Mutations associated with phenotypic rifampin resistance
    rpoB531148/24261.254.7-67.361.254.7-67.3100
    rpoB52647/24219.414.6-25.079.874.1-84.6100
    rpoB51618/2427.44.5-11.587.282.3-91.1100
    rpoB53312/2425.02.5-8.590.986.6-94.2100
    rpoB5137/2422.91.1-5.993.890.0-96.5100
    rpoB5118/2423.31.4-6.494.290.5-96.8100
    rpoB5224/2421.70.4-4.295.992.5-98.0100
    rpoB5182/2420.80.1-3.095.992.5-98.0100
    rpoB5152/2420.80.1-3.095.992.5-98.0100
    rpoB5341/2420.40.0-2.395.992.5-98.0100
    rpoB5291/2420.40.0-2.395.992.5-98.0100
    rpoB5191/2420.40.0-2.396.393.1-98.3100
Additional mutation associated with MDR
    embB30692/24238.031.9-44.538.031.9-44.5100