TABLE 2.

Distribution of mutations in katG, inhA, and two regulatory regions (oxyR-ahpC intergenic region and promoter of mabA-inhA) among 242 MDR isolates from tuberculosis cases in Shanghai, China

LocusNucleotide changeAmino acid changeNo. (%) of isolates (n = 242)
katG315 AGC→ACCSer→Thr150 (62.0)
AGC→ACGSer→Thr2 (0.8)
AGC→AACSer→Asn8 (3.3)
katG295 CAG→CCGGln→Pro1 (0.4)
katG299 and ahpC-15GGC→AGC and C→TGly→Ser1 (0.4)
katG322 ACG→GCGThr→Ala1 (0.4)
katG315 and inhA-15AGC→ACC and C→TSer→Thr6 (2.5)
katG 315 and inhA-8AGC→ACC and T→CSer→Thr1 (0.4)
katG315 and ahpC-15AGC→ACC and C→TSer→Thr1 (0.4)
katG315 and ahpC-32AGC→ACC and G→ASer→Thr1 (0.4)
katG315 and ahpC-52AGC→ACC and C→TSer→Thr1 (0.4)
katG315 and ahpC-10AGC→ACC and G→ASer→Thr1 (0.4)
katG315 and ahpC-6AGC→ACC and G→ASer→Thr1 (0.4)
katG315 and inhA3AGC→ACC and GGA→GGCSer→Thr and Gly→Gly2 (0.8)
katG315, inhA3, and ahpC-39AGC→AAC, GGA→GGC, and C→TSer→Asn and Gly→Gly2 (0.8)
inhA3 and ahpC-10GGA→GGC and C→TGly→Gly2 (0.8)
inhA25, inhA-8, and ahpC-6ATC→ACC, T→C and, G→AIle→Thr2 (0.8)
inhA-15C→T11 (4.6)
inhA-15 and ahpC-10C→T and C→T3 (1.2)
inhA-8 and ahpC-6T→C and G→A1 (0.4)
ahpC-39C→T2 (0.8)
ahpC-32G→A1 (0.4)
ahpC-12C→T6 (2.5)
ahpC-10C→T3 (1.2)
ahpC-9G→A3 (1.2)
ahpC-6G→A3 (1.2)
Wild type26 (10.7)