TABLE 1.

Values of pharmacokinetic parameters for unbound colistin following subcutaneous administration of single doses (5 to 40 mg/kg) in neutropenic infected mice

ParameterResult for a single subcutaneous dose of:
5 mg/kg10 mg/kg20 mg/kg40 mg/kg
Cmax (mg/liter)0.311.443.298.89
Tmax (min)6030120120
V/F (L/kg)10.14.634.883.27
CL/F (ml/min/kg)16946.829.216.4
t1/2 (min)17.968.780.283.6