TABLE 2.

PK/PD model parameter estimates predicting viable counts at 24 h for the fAUC/MIC index for colistin against all three strains of P. aeruginosa in the thigh and lung infection models

Model and strainEmax (log10 CFU/organ)E0 (log10 CFU/organ)EC50γ
Thigh infection
    ATCC 278536.29 (8.2)a8.97 (2.9)18.8 (11.8)2.36 (23.1)
    PAO15.97 (6.1)8.34 (1.9)22.7 (12.6)1.51 (16.2)
    19056b6.23 (10.1)7.98 (3.0)19.5 (20.4)1.13 (24.0)
Lung infection
    ATCC 278537.58 (16.1)9.34 (3.4)16.8 (48.8)0.61 (20.2)
    PAO17.36 (26.1)8.97 (3.4)31.7 (87.9)0.54 (30.0)
    19056b6.86 (12.7)8.85 (2.9)12.4 (40.0)0.54 (18.4)
  • a Data in parentheses are the percent relative standard error.

  • b Multidrug-resistant mucoid strain.