TABLE 1.

Distribution of mutations in the rpoB gene among 242 MDR isolates from tuberculosis cases in Shanghai, China

LocusNucleotide changeAmino acid changeNo. (%) of isolates (n = 242)
rpoB531 TCG→TTGSer→Leu143 (59.1)
TCG→TGGSer→Trp2 (0.8)
TCG→TTTSer→Phe1 (0.4)
rpoB531 and rpoB526TCG→TGG and CAC→AACSer→Trp and His→Asn1 (0.4)
TCG→GGG and CAC→CGCSer→Gly and His→Arg1 (0.4)
rpoB526 CAC→GACHis→Asp13 (5.4)
CAC→TACHis→Tyr15 (6.2)
CAC→CGCHis→Arg6 (2.5)
CAC→AACHis→Asn3 (1.2)
CAC→CCCHis→Pro1 (0.4)
CAC→CTCHis→Leu1 (0.4)
rpoB526 and rpoB511CAC→AAC and CTG→CCGHis→Asn and Leu→Pro2 (0.8)
rpoB526 and rpoB533CAC→AAC and CTG→CCGHis→Asn and Leu→Pro2 (0.8)
rpoB526 and rpoB534CAC→AAC and GGG→CGGHis→Asn and Gly→Arg1 (0.4)
rpoB526 and rpoB529CAC→CGC and CGA→CTGHis→Arg and Arg→Leu1 (0.4)
rpoB516 GAC→GTCAsp→Val12 (5.0)
GAC→CCCAsp→Pro1 (0.4)
rpoB516 and rpoB511GAC→GGC and CTG→CCGAsp→Gly and Leu→Pro1 (0.4)
GAC→GTC and CTG→CCGAsp→Gly and Leu→Pro2 (0.8)
rpoB516 and rpoB518GAC→GGC and CTG→CCGAsp→Gly and Leu→Pro1 (0.4)
rpoB516 and rpoB533GAC→GCC and CTG→CCGAsp→Ala and Leu→Pro1 (0.4)
rpoB533 CTG→CCGLeu→Pro7 (2.9)
rpoB533 and rpoB515CTG→CCG and ATG→GTGLeu→Pro and Met→Val1 (0.4)
rpoB533 and rpoB518CTG→CCG and ATG→GTGLeu→Pro and Met→Val1 (0.4)
rpoB513 CAA→CCAGln→Pro4 (1.7)
CAA→AAAGln→Lys1 (0.4)
rpoB513 and rpoB511CAA→CCA and CTG→CCGGln→Pro and Leu→Pro2 (0.8)
rpoB515 and rpoB511ATG→CTG and CTG→CCGMet→Leu and Leu→Pro1 (0.4)
rpoB522 TCG→TGGSer→Trp1 (0.4)
TCG→TTGSer→Leu3 (1.2)
rpoB519 AAC→AAGAsn→Lys1 (0.4)
Wild type9 (3.7)