TABLE 3.

Median Cmax and AUC0-∞ values for CQ and DECQ after different CQ dose regimens for 1,000 nonpregnant and 1,000 pregnant hypothetical subjectsa

Group (no. of tablets × no. of daily doses)CQDECQ
Cmax (μg/liter)AUC0-∞ (μg·h/liter)Cmax (μg/liter)AUC0-g∞ (μg·h/liter)
Nonpregnant (3 × 3)37650,02818641,255
Pregnant (3 × 3)296 (79)35,659 (71)139 (75)23,876 (58)
Pregnant (4 × 3)395 (105)47,545 (95)185 (100)31,835 (77)
Pregnant (5 × 3)494 (131)59,431 (119)232 (125)39,793 (96)
  • a The numbers in parentheses represent the simulated medians for pregnant subjects expressed as percentages of that for the standard dose of 3 tablets (450 mg CQ base) in 3 daily doses for nonpregnant subjects.