TABLE 1.

Parameter estimates of the descriptive model (model C)

ParameterVariableUnitCFUo estimate (%SE)Range from case deletion
Log10 (initial inoculum)Log10 (CFUo)106, 6.13 (0.3);6.12-6.14;
    107, 7.35 (0.4);    7.27-7.36;
    108, 8.01 (0.2)    7.95-8.03
Maximum population sizeLog (CFUmax)9.17 (0.4)9.16-9.20
First-order growth rate constant kg h−1106, 2.55 (4.3); 107, 0.567 (8.3); 108, 0.319 (8.5)2.46-2.68, 0.541-0.876, 0.309-0.575
First-order rate constant for natural death kd h−1106, 1.36 (6.8); 107, 0.0925 (14.4); 108, fixed to 0a1.27-1.49, 0.0823-0.113, fixed to 0
Drug concn causing 50% of maximum inhibitionIC50, CWmg/liter106, 0.428 (10.9); 107, 0.337 (16.9); 108, 0.185 (23.2)0.360-0.472, 0.195-0.386, 0.0732-0.303
MTT for turnover of cell wallMTTCW = 1/kout, CWh0.985 (13)0.863-1.11
  • a The parameter was estimated to be 0.001 but was fixed at zero, as this small estimate caused a convergence problem. This did not alter the objective function.