TABLE 3.

Hydrolysis rates of KPC variants determined by using extracts from KPC E. coli transformants

SubstrateHydrolysis rate (nmol/min/mg)
KPC-2KPC-4KPC-5
Cephalothin1,310 ± 8172 ± 22368 ± 58
Cephalothin + Clava487 ± 5420 ± 148 ± 4
Cefotaxime65 ± 1253 ± 450 ± 5
Cefotaxime + Clav25 ± 16 ± 0.47 ± 3
Ceftazidime3 ± 17 ± 16 ± 0.2
Imipenem412 ± 1269 ± 4116 ± 5
  • a Clav, clavulanic acid at 100 μM.