TABLE 2.

Plasma, ELF, and AC PK/PDa parameters

CompartmentCmin (μg/ml)Cmaxb (μg/ml)Cmax/MIC90 ratioTmax (h)AUC0-12 (μg·h/ml)AUC0-24/MIC90 ratioc
Plasma1.542.08 ± 0.934.153.621.987.6
ELF1.021.86 ± 1.303.725.018.373.2
AC46.287.7 ± 65.01755.07152,860
  • a The parameters were derived using total (i.e., unbound plus bound) drug concentrations (see the text).

  • b Mean values ± SD are shown.

  • c Based on the AUC0-24, which was twice the AUC0-12.