TABLE 2.

Antimicrobial susceptibilities of clinical isolates and blaKPC transformants

Antimicrobial agentMIC (μg/ml) for the following strain (KPC)a:
PS10 (KPC-2)E624 (KPC-4)PS28 (KPC-5)E. coli TOP10TOP10 (KPC-2)TOP10 (KPC-4)TOP10 (KPC-5)
Piperacillin + tazobactam>256>641281>256128>256
Ceftazidime64>641280.1232>128128
CefotaximeNDb>64ND<0.06646464
CefoxitinND>64ND432816
CefepimeND64ND<0.0616816
AztreonamND>64ND<0.12>128>128>128
Imipenem>64>32>640.121624
Imipenem + clavulanic acidNDNDND0.124<0.060.12
Meropenem>64>32>64<0.06812
ErtapenemND>16ND<0.061628
  • a Strains include the E. coli recipient strain TOP10 and transformants harboring the pACYC184 vector with cloned blaKPCs.

  • b ND, not determined.