TABLE 2.

Parametric 90% CIs for the mean pharmacokinetic properties of dihydroartemisinin and piperaquine after the administration of a single oral dose of Arterakine and Artekin (reference formulation)

Drug and parameterArterakine/Artekin point estimator (%)90% CIa
Dihydroartemisinin
    Cmax136.4100.6-152.8b
    AUC0-last122.0105.4-137.3b
    AUC0-∞121.6105.0-137.3b
    Cmax/AUC0-∞105.992.9-114.8
    t1/295.288.7-105.3
Piperaquine
    Cmax116.591.3-142.0b
    AUC0-last111.7101.6-123.6
    AUC0-∞115.4106.5-128.5b
    Cmax/AUC0-∞97.778.3-121.3
    t1/2100.686.4-125.2b
  • a Determined by using log-transformed data.

  • b Value falls outside the range of 80 to 125%.