TABLE 3.

Combinations of mutations in genes reported to affect regulation of mexA expression

Mutation(s) detectedNo. of isolates with mutation
mexRnalCnalDClinical isolatesControl strains
Arg83→CysGly71→GluAsp187→His11ab
Arg83→CysGly71→GluAsp187→His/Leu201→Pro2
Arg83→CysGly71→GluNone1
Arg83→CysGly71→Glu/Ser209→ArgAsp187→His/Leu201→Pro1
Val126→GluGly71→GluAsp187→His1
Val126→GluGly71→GluNone11
Val126→GluGly71→Glu/Ser209→ArgAla145→Thr1
Val126→GluGly71→Glu/Ser209→ArgNone1
Val126→GluGly71→Glu/Ala186→ThrAsp187→His1
Val126→GluGly71→Glu/Ser209→Arg/Ala78→ThrNone1
NoneGly71→GluAsp187→His/Leu201→Pro1
NoneGly71→GluNone3
NoneGly71→Glu/Ser209→ArgThr188→Ala1
NoneGly71→Glu/Ser209→ArgNone1
NoneGly71→Glu/Ala186→ThrNone1
NoneGly71→Glu/Ser209→Arg/Ala145→ValNone1
NoneNoneNone11
  • a All isolates were representatives of the Liverpool epidemic strain.

  • b —, no isolate.