Genes up- and downregulated in C. albicans in response to FLC, AMD, and both drugs in combination

GeneCategoryUp- and downregulation (fold) inductiona in strain:
36082 (WT)1002 (WT)3795 [erg11(F136L/K134R)]610 (WT)611 (overexpression CDR1)
MID1Ca2+ pumps, channels, and transporters0.
CCH1Ca2+ pumps, channels, and transporters1.
PMC1Ca2+ pumps, channels, and transporters1.5282.31.26520.91.0121.628.60.935.97.90.9257.4
CRZ1Calmodulin-calcineurin pathway1.
CMD1Calmodulin-calcineurin pathway1.
FKS2Cell wall1.
TUS1Cell wall1.
SKN1Cell wall1.
WSC2Cell wall1.
RIM101Alkaline pH and cation overload response1.
GYP7GTPase activity, vesicle transport1.
TAC1bTranscription factor activity1.335.96.21.344.
ZCF39Transcription factor activity1.
RLM1cTranscription factor activity1.
CLB2Cell cycle0.
ACE2Cell cycle1.
CLN1Cell cycle1.
HSP90Heat shock protein. molecular chaperone0.
FOX2Oxidation of fatty acids1.
ERG1Ergosterol biosynthesis2.
ERG11Ergosterol biosynthesis2.
ERG3Ergosterol biosynthesis1.
ERG6Ergosterol biosynthesis2.
NRG1Morphogenesis and hyphal formation1.
TUP1Morphogenesis and hyphal formation0.
RFG1Morphogenesis and hyphal formation0.
UME6Morphogenesis and hyphal formation0.
  • a The data represent the arithmetic mean of three repetitions. Numbers in boldface represent upregulated genes (>2-fold). Numbers in italics represent downregulated genes (>2-fold). F, fluconazole; A, amiodarone.

  • b Related to azole resistance by transcriptional activation of the CDR genes (8).

  • c Related to stress response (37).