TABLE 3

Multivariate analysis of factors associated with low and potentially toxic voriconazole plasma concentrationse

VariableCoefficientSEP value
Age−0.0040.0080.642
Weight−0.0070.0070.345
Oral administrationa−0.0050.3350.034
Sex−0.1000.1980.618
CYP2C19 genotypeb
    Heterozygous extensive metabolizer0.6100.2950.045
    Ultrarapid metabolizer−0.6610.2880.027
    Poor metabolizer1.3830.4210.002
Concomitant medication
    Glucocorticoidsc−3.1750.433<0.001
    Tacrolimus/cyclosporine−0.1610.2210.469
    Proton pump inhibitorsd1.2910.309<0.001
  • a Compared to intravenous administration.

  • b Compared to homozygous extensive metabolizers.

  • c Methylprednisolone, prednisone, and prednisolone.

  • d Pantoprazole and omeprazole.

  • e R2 = 0.932; n = 832 voriconazole trough measurements.