TABLE 2.

Resistance to NIM811 is mediated by viral RNA

Origin of total RNANIM811 EC50 (μM)aBILN2061 EC50 (nM)
RNA transfected into cured CsA/NIMr cells
    WT replicon0.12
    DMSOr0.17
RNA transfected into Huh-cure cells
    CsA/NIM811r1.5 (17.9)1.5
    DMSOr0.084 (1.0)1.4
  • a Values in parentheses are the fold changes.