TABLE 1

Demographic and clinical features of patients in the two treatment groups at the initiation of treatment

ParameteraValue for the parameterbP value
Total patient population (n = 77)Conventional-dose group (n = 36)Low-dose group (n = 41)
Clinical characteristics
    Age (yr)66.1 ± 13.767.0 ± 14.165.4 ± 13.20.49
    Gender (no. of male patients/no. of female patients)47/3019/1728/130.16
    Body wt (kg)54.8 ± 10.551.2 ± 9.457.9 ± 10.40.008
    Body mass index (kg/m2)21.4 ± 3.420.9 ± 3.521.9 ± 3.30.4
Underlying disease (no. of patients [%])
    Collagen vascular disease33 (42.9)18 (50.0)15 (36.6)0.24
    Rheumatoid arthritis19 (24.7)11 (30.6)8 (19.5)0.26
    Hematological malignancy17 (22.1)8 (22.2)9 (22.0)0.98
    Solid tumor13 (16.9)5 (13.9)8 (19.5)0.51
    Interstitial lung disease3 (3.9)1 (2.8)2 (4.9)0.63
    Others11 (14.3)4 (11.1)7 (17.1)0.46
Therapy for underlying disease (no. of patients [%])
    Corticosteroid only35 (45.5)16 (44.4)19 (46.3)0.87
    Corticosteroid with other agents29 (37.7)13 (36.1)16 (39.0)0.79
    Without corticosteroids13 (16.9)7 (19.4)6 (14.6)0.57
Primary prophylaxis with TMP-SMX (no. of patients [%])1 (1.3)1 (2.8)0 (0)0.28
Laboratory findings
    PaO2/FiO2 ratio231.0 ± 96.2238.6 ± 94.1223.9 ± 97.50.58
    A-a DO2 (torr)143.7 ± 129.8119.0 ± 106.2166.7 ± 144.70.35
    White blood cell count (×109/liter)8.4 ± 4.37.5 ± 3.69.3 ± 4.70.08
    Neutrophil count (×109/liter)7.2 ± 4.26.2 ± 3.18.1 ± 4.80.08
    Lymphocyte count (×109/liter)0.8 ± 0.50.8 ± 0.60.8 ± 0.50.55
    Hemoglobin (g/dl)10.8 ± 2.210.5 ± 2.111.1 ± 2.30.23
    Platelet count (×109/liter)191.2 ± 102.8180.0 ± 88.8201.0 ± 111.00.44
    Total protein (g/dl)5.5 ± 1.05.6 ± 1.05.4 ± 0.90.26
    Albumin (g/dl)2.7 ± 0.72.8 ± 0.72.7 ± 0.60.73
    Lactate dehydrogenase (IU/liter)431.5 ± 222.3432.0 ± 250.6431.1 ± 194.10.63
    Urea nitrogen (mEq/liter)28.3 ± 18.929.0 ± 21.227.8 ± 16.60.6
    Creatinine (mg/dl)1.4 ± 1.41.7 ± 1.91.2 ± 0.90.95
    C-reactive protein (mg/dl)8.9 ± 6.98.9 ± 5.88.9 ± 7.70.71
    KL-6 (IU/ml)1,171.9 ± 1,619.5770.2 ± 526.71,487.5 ± 2,058.90.22
    β-d-Glucan (pg/ml)307.2 ± 1097.2201.5 ± 248.1400.0 ± 1,479.30.9
    Creatinine clearance (ml/min)59.3 ± 36.153.0 ± 38.064.8 ± 33.30.03
SOFA score4.1 ± 2.74.2 ± 3.03.9 ± 2.30.91
  • a A-a DO2, alveolar-arterial oxygen difference; PaO2/FiO2, arterial partial pressure of oxygen/fraction of inspiratory oxygen; SOFA, sequential organ failure assessment; TMP-SMX, trimethoprim-sulfamethoxazole.

  • b Values are presented as means ± standard deviations unless otherwise indicated.